GAMBARAN KADAR ALBUMIN PADA PENDERITA DEMAM TIFOID DI RS ISLAM SITI KHODIJAH KOTA PALEMBANG

Latar Belakang: Demam tifoid disebabkan oleh bakteri Salmonella typhi yang
memicu respons inflamasi sistemik sehingga menghambat produksi albumin di
hati. Albumin merupakan protein yang terdapat di dalam plasma darah dengan
jumlah terbanyak diantara protein lainnya. Tujuan Penelitian: Untuk mengetahui
gambaran kadar albumin pada penderita demam tifoid di RS Islam Siti Khodijah
Kota Palembang Tahun 2025. Metode Penelitian: Penelitian dilakukan secara
deskriptif observasional dengan cross sectional. Populasi penelitian ini adalah
penderita demam tifoid di RS Islam Siti Khodijah Kota Palembang Tahun 2025.
Sampel berjumlah 30 orang menggunakan teknik accidental sampling. Metode
pemeriksaan menggunakan metode BCG. Hasil Penelitian: Gambaran distribusi
frekuensi kadar albumin rendah sebesar 56,6%, normal sebesar 36,7%, dan tinggi
sebesar 6,7%. Katagori durasi demam (≤1 minggu) kadar albumin rendah sebesar
31,6%, normal sebesar 57,9%, dan tinggi sebesar 10,5%. Katagori durasi (>1
minggu) kadar albumin rendah sebesar 100,0%, normal dan tinggi tidak
didapatkan 0,0%. Katagori konsumsi antibiotik kadar albumin rendah dan normal
tidak didapatkan 0,0%, dan tinggi sebesar 100,0%. Katagori tidak konsumsi
antibiotik kadar albumin rendah sebesar 58,6%, normal sebesar 37,9% dan tinggi
sebesar 3,4%. Kesimpulan: Berdasarkan analisa, semakin lama seseorang
mengalami demam tifoid maka akan terjadi penurunan kadar albumin. Saran:
Bagi seseorang yang menderita demam tifoid sebaiknya memeriksakan kadar
albumin.

Background: Typhoid fever is caused by Salmonella typhi, which triggers a
systemic inflammatory response that inhibits albumin production in the liver.
Albumin is the most abundant protein in blood plasma. Objective: To determine
the albumin level profile in typhoid fever patients at Siti Khodijah Islamic
Hospital, Palembang City, in 2025. Methods: This study employed a descriptive
observational design with a cross-sectional approach. The population consisted of
typhoid fever patients at Siti Khodijah Islamic Hospital in 2025. A total of 30
samples were selected using accidental sampling. Albumin levels were measured
using the BCG (Bromocresol Green) method. Results: The distribution of albumin
levels was as follows: low (56.6%), normal (36.7%), and high (6.7%). Among
patients with fever duration ≤1 week, albumin levels were low in 31.6%, normal in
57.9%, and high in 10.5%. For those with fever >1 week, 100.0% had low
albumin levels, with no normal or high levels detected. In the antibiotic
consumption category, 100.0% had high albumin levels, with no low or normal
levels observed. Among those who did not consume antibiotics, 58.6% had low
albumin levels, 37.9% were normal, and 3.4% were high. Conclusion: The
analysis indicates that the longer a person suffers from typhoid fever, the more
likely their albumin levels are to decrease. Recommendation: Typhoid fever
patients are advised to have their albumin levels checked regularly.