KORELASI KADAR C-REACTIVE PROTEIN (CRP) DENGAN JUMLAH TROMBOSIT PADA PASIEN DEMAM BERDARAH DENGUE DI RUMAH SAKIT ISLAM SITI KHADIJAH KOTA PALEMBANG

Latar Belakang : Virus dengue adalah penyebab penyakit infeksi akut yang
dikenal sebagai demam berdarah dengue (DBD). Gigitan nyamuk betina Aedes
Aegypti Salah satu manifestasi dari DBD adalah penurunan jumlah trombosit
(trombositopenia) dan peningkatan respon inflamasi yang dapat diukur melalui
kadar C-Reactive Protein (CRP). CRP adalah protein fase akut yang meningkat
sebagai respons terhadap infeksi dan inflamasi. Pemeriksaan CRP dan jumlah
trombosit dapat membantu dalam penilaian kondisi klinis pasien DBD.
Tujuan Penelitian : Untuk mengetahui korelasi kadar CRP dengan jumlah
trombosit pada pasien DBD di RS Islam Siti Khadijah Kota Palembang tahun 2025.
Metode Penelitian : Penelitian ini merupakan penelitian analitik observasional
dengan pendekatan cross sectional. Sampel berjumlah 35 pasien DBD yang
diperoleh melalui teknik accidental sampling. Kadar CRP diperiksa menggunakan
metode aglutinasi lateks dan data jumlah trombosit diperoleh dari rekam medis
pasien. Hasil Penelitian : kadar CRP normal sebanyak 71,4% dan kadar CRP tidak
normal 28,6%. Jumlah trombosit tidak normal sebanyak 91,4%, dan untuk jumlah
trombosit normal 8.6%. Secara statistik tidak ada korelasi antara kadar CRP dengan
Jumlah Trombosit (0,656 >). Kesimpulan : tidak ada korelasi yang bermakna
antara kadar CRP dengan jumlah trombosit pada pasien DBD.

Background : Dengue virus is the cause of an acute infectious disease known as
dengue hemorrhagic fever (DHF). Aedes Aegypti female mosquito bite One of the
manifestations of dengue is a decrease in platelet count (thrombocytopenia) and an
increase in inflammatory response which can be measured through C-Reactive
Protein (CRP) levels. CRP is an acute phase protein that increases in response to
infection and inflammation. Examination of CRP and platelet count can be helpful
in the assessment of the clinical condition of dengue patients. Research Objective
: To determine the correlation between CRP levels and platelet counts in dengue
patients at Siti Khadijah Islamic Hospital, Palembang City in 2025. Research
Method : This study is an observational analytical research with a cross sectional
approach. A sample of 35 dengue patients was obtained through accidental
sampling techniques. CRP levels were checked using the latex agglutination method
and platelet count data was obtained from the patient's medical records. Research
Results : normal CRP levels are 71.4% and abnormal CRP levels are 28.6%. The
number of abnormal platelets was 91.4%, and for the normal platelet count it was
8.6%. Statistically, there was no correlation between CRP levels and platelet counts
(0.656 > ). Conclusion : there was no significant correlation between CRP levels
and platelet counts in dengue patients.