Korelasi Faktor-Faktor Hemodialisis dengan Kadar Ureum Pra-Hemodialisis Pasien Gagal Ginjal Kronik di Rumah Sakit Islam Siti Khadijah Palembang

Latar Belakang: Kadar ureum pra-hemodialisis dipengaruhi oleh berbagai faktor yang berkaitan dengan pelaksanaan hemodialisis, antara lain frekuensi tindakan hemodialisis, kepatuhan pasien terhadap jadwal hemodialisis, dan lama menjalani terapi hemodialisis. Faktor-faktor tersebut berperan dalam menentukan efektivitas pembuangan ureum dari dalam tubuh pada pasien gagal ginjal kronik (GGK). Tujuan: Menganalisis korelasi faktor-faktor hemodialisis dengan kadar ureum pra-hemodialisis pada pasien GGK di RS Islam Siti Khadijah Palembang. Metode: Penelitian observasional analitik dengan pendekatan retrospektif menggunakan data rekam medis pasien GGK yang menjalani hemodialisis di RS Islam Siti Khadijah Palembang periode Mei 2025–Mei 2026. Sampel berjumlah 104 pasien yang dipilih menggunakan total sampling. Analisis dilakukan menggunakan uji korelasi Spearman dengan tingkat kemaknaan p<0,05. Hasil: Sebagian besar pasien menjalani hemodialisis <2 kali per minggu (51%), tidak patuh terhadap kehadiran hemodialisis (51%), dan telah menjalani hemodialisis ≥1 tahun (77,9%). Rerata kadar ureum pra-hemodialisis sebesar 120,46 mg/dL (95% CI: 110,18–130,75 mg/dL). Terdapat korelasi negatif kuat antara frekuensi hemodialisis dan kadar ureum pra-hemodialisis (p=0,001; r=-0,658), korelasi negatif kuat antara kepatuhan kehadiran dan kadar ureum pra-hemodialisis (p=0,001; r=-0,636), serta korelasi positif sedang antara lama menjalani hemodialisis dan kadar ureum pra-hemodialisis (p=0,001; r=0,505). Kesimpulan: Terdapat korelasi bermakna antara faktor-faktor hemodialisis dengan kadar ureum pra-hemodialisis. Frekuensi hemodialisis dan kepatuhan kehadiran berkorelasi negatif kuat, sedangkan lama menjalani hemodialisis berkorelasi positif sedang terhadap kadar ureum pra-hemodialisis.

Background: Pre-hemodialysis blood urea levels are influenced by hemodialysis-related factors, including treatment frequency, patient adherence to the hemodialysis schedule, and duration of therapy. These factors affect the effectiveness of urea removal in patients with chronic kidney disease (CKD). Objective: To analyze the correlation between hemodialysis-related factors and pre-hemodialysis urea levels in CKD patients at Siti Khadijah Islamic Hospital Palembang. Methods: This analytical observational study employed a retrospective approach using medical record data of CKD patients undergoing hemodialysis at Siti Khadijah Islamic Hospital Palembang from May 2025 to May 2026. A total of 104 patients were selected using total sampling. Data were analyzed using Spearman's correlation test with a significance level of p<0.05. Results: Most patients underwent hemodialysis less than twice per week (51%), were non-adherent to scheduled hemodialysis attendance (51%), and had been receiving hemodialysis for at least one year (77.9%). The mean pre-hemodialysis urea level was 120.46 mg/dL (95% CI: 110.18–130.75 mg/dL). There was a strong negative correlation between hemodialysis frequency and pre-hemodialysis urea levels (p=0.001; r=-0.658), a strong negative correlation between attendance adherence and pre-hemodialysis urea levels (p=0.001; r=-0.636), and a moderate positive correlation between duration of hemodialysis and pre-hemodialysis urea levels (p=0.001; r=0.505). Conclusion: There was a significant correlation between hemodialysis-related factors and pre-hemodialysis urea levels. Hemodialysis frequency and attendance adherence showed strong negative correlations, whereas duration of hemodialysis showed a moderate positive correlation with pre-hemodialysis urea levels.