KORELASI KADAR TROMBOSIT DENGAN MEAN PLATELET VOLUME (MPV) PADA PASIEN DEMAM BERDARAH DENGUE (DBD) DI RSUD PALEMBANG BARI

FITRIANTY, INTAN (2026) KORELASI KADAR TROMBOSIT DENGAN MEAN PLATELET VOLUME (MPV) PADA PASIEN DEMAM BERDARAH DENGUE (DBD) DI RSUD PALEMBANG BARI. Diploma thesis, POLTEKKES KEMENKES PALEMBANG.

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Abstract

Latar Belakang: Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan masyarakat utama di wilayah tropis dan subtropis, termasuk Indonesia. Salah satu manifestasi hematologis utama pada DBD adalah trombositopenia. Mean Platelet Volume (MPV) merupakan parameter yang mencerminkan ukuran rata-rata trombosit dan dapat menilai aktivitas trombopoiesis sebagai respons kompensasi sumsum tulang terhadap penurunan trombosit. Tujuan: untuk mengetahui korelasi antara kadar trombosit dengan MPV pada pasien DBD di RSUD Palembang BARI.
Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Sampel penelitian adalah pasien DBD yang melakukan pemeriksaan darah lengkap di RSUD Palembang BARI periode Januari 2025 hingga April 2026, diperoleh sebanyak 210 sampel. Teknik sampling yang digunakan adalah purposive sampling. Analisis data dilakukan secara univariat untuk mengetahui distribusi statistik kadar trombosit dan MPV, serta analisis bivariat menggunakan uji korelasi Pearson. Hasil: Rata-rata kadar trombosit pada pasien DBD adalah 59,51 x 103/µL (SD ±25,35) dengan nilai terendah 10 x 103/µL dan tertinggi 142 x 103/µL. Rata-rata MPV adalah 10,91 fL (SD ±1,23) dengan nilai terendah 7,9 fL dan tertinggi 14,8 fL. Hasil uji korelasi Pearson menunjukkan koefisien korelasi (r) sebesar -0,382 dengan nilai signifikansi p = 0,000 (p < 0,05). Kesimpulan: Terdapat korelasi negatif yang signifikan antara kadar trombosit dan MPV pada pasien DBD di RSUD Palembang BARI dengan kekuatan korelasi lemah.

Background: Dengue Hemorrhagic Fever (DHF) remains a major public health problem in tropical and subtropical regions, including Indonesia. One of the main hematological manifestations in DHF is thrombocytopenia. Mean Platelet Volume (MPV) is a parameter that reflects the average platelet size and can assess thrombopoiesis activity as a bone marrow compensatory response to decreased platelet count. Objective: To determine the correlation between platelet count and MPV in DHF patients at Palembang BARI Regional General Hospital. Methods: This study was an observational analytic study with a cross-sectional design. The research sample consisted of DHF patients who underwent complete blood examination at Palembang BARI Regional General Hospital from January 2025 to April 2026 obtaining 210 samples. The sampling technique used was purposive sampling. Data analysis was performed univariately to determine the statistical distribution of platelet count and MPV, and bivariately using the Pearson correlation test. Results: The mean platelet count in DHF patients was 59.51 x 103/µL (SD ±25.35) with the lowest value of 10 x 103/µL and the highest of 142 x 103/µL. The mean MPV was 10.91 fL (SD ±1.23) with the lowest value of 7.9 fL and the highest of 14.8 fL. The Pearson correlation test results showed a correlation coefficient (r) of -0.382 with a significance value of p = 0.000 (p < 0.05). Conclusion: There is a significant negative correlation between platelet count and MPV in DHF patients at Palembang BARI Regional General Hospital with a weak correlation strength.

Item Type: Thesis (Diploma)
Uncontrolled Keywords: Demam Berdarah Dengue (DBD), trombosit, Mean Platelet Volume (MPV), korelasi, trombositopenia
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: Jurusan Teknologi Laboratorium Medis > 13350-D4 Teknologi Laboratorium Medis
Depositing User: Unnamed user with email D4tlm
Date Deposited: 28 Jul 2026 04:59
Last Modified: 28 Jul 2026 04:59
URI: http://rama.poltekkespalembang.ac.id/id/eprint/3451

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