GAMBARAN KADAR SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT) PADA PEROKOK AKTIF DI KELURAHAN LOROK PAKJO KOTA PALEMBANG TAHUN 2026

Latar Belakang: Merokok merupakan salah satu faktor risiko yang dapat menyebabkan gangguan fungsi hati akibat paparan zat toksik seperti nikotin, tar, dan karbon monoksida. Kerusakan sel hati dapat menyebabkan peningkatan kadar Serum Glutamic Pyruvic Transaminase (SGPT) yang digunakan sebagai indikator fungsi hati. Tujuan Penelitian: Mengetahui gambaran kadar Serum Glutamic Pyruvic Transaminase (SGPT) pada perokok aktif di Kelurahan Lorok Pakjo Kota Palembang Tahun 2026. Metode Penelitian: Penelitian ini menggunakan metode deskriptif dengan pendekatan cross sectional. Populasi penelitian berjumblah 110 responden dan Sampel penelitian berjumlah 33 perokok aktif yang dipilih menggunakan teknik purposive sampling. Pemeriksaan kadar SGPT dilakukan dengan metode Kinetik Enzimatik berdasarkan International Federation of Clinical Chemistry (IFCC). Analisis data dilakukan secara univariat dan bivariat dalam bentuk distribusi frekuensi. Hasil Penelitian: Dari 33 responden, diperoleh 28 responden (84,8%) memiliki kadar SGPT normal dan 5 responden (15,2%) memiliki kadar SGPT meningkat. Berdasarkan lama merokok, peningkatan SGPT ditemukan pada perokok dengan lama merokok ≥10 tahun sebanyak 5 responden (17,9%). Berdasarkan frekuensi merokok, peningkatan SGPT ditemukan pada perokok sedang sebanyak 2 responden (14,3%) dan perokok berat sebanyak 3 responden (30,0%). Berdasarkan indeks massa tubuh (IMT), peningkatan SGPT ditemukan pada kategori underweight sebesar 12,5%, normal 18,8%, dan overweight 11,1%. Berdasarkan konsumsi minuman beralkohol, peningkatan SGPT ditemukan pada 75,0% responden yang mengonsumsi alkohol ringan dan 6,9% responden yang tidak mengonsumsi alkohol. Kesimpulan: kadar SGPT meningkat. ditemukan pada responden dengan lama merokok kategori lama, frekuensi merokok berat, dan konsumsi alkohol ringan.

Background: Smoking is one of the risk factors that may lead to liver dysfunction due to exposure to toxic substances such as nicotine, tar, and carbon monoxide. Hepatocellular damage can result in elevated Serum Glutamic Pyruvic Transaminase (SGPT) levels, which serve as an indicator of liver function. Objective: To describe the levels of Serum Glutamic Pyruvic Transaminase (SGPT) among active smokers in Lorok Pakjo Subdistrict, Palembang City, in 2026. Methods: This study employed a descriptive design with a cross-sectional approach. A total of 33 active smokers were selected using purposive sampling. SGPT levels were measured using the enzymatic kinetic method based on the standards of the International Federation of Clinical Chemistry (IFCC). Data were analyzed using univariate and bivariate analyses and presented as frequency distributions. Results: Of the 33 respondents, 28 (84.8%) had normal SGPT levels, while 5 (15.2%) had elevated SGPT levels. Elevated SGPT levels were more frequently observed among respondents with a smoking duration of ≥10 years, moderate to heavy smoking frequency, and light alcohol consumption. Conclusion: The majority of active smokers in Lorok Pakjo Subdistrict, Palembang City, had normal SGPT levels. However, elevated SGPT levels were more commonly found among respondents with longer smoking duration, higher smoking frequency, and light alcohol consumption.